Investigating the efficacy of topical application of Ipomoea carnea herbal cream in preventing skin damage induced by UVB radiation in a rat model

Ultraviolet-B irradiation is a common environmental stressor that has detrimental effects on human skin. Natural sunscreens are well-known for their ability to benefit inflamed sunburn and dry This study examined the effect of formulated Ipomoea carnea herbal cream UVB-induced skin damage. We screened bioactive compounds I. crude extract, showing significant antioxidant. Additionally, we evaluated cytotoxicity, revealing extract less toxicity vero cells (IC50 98.45 μg/mL) than A375 48.95 μg/mL). Based this, (FIHC) at 50, 100 200 mg concentrations its organoleptic characteristics. Then, rats were exposed UVB radiation (32,800 J/m2) four times/week (on alternate days) before was applied topically dorsal surface. Under stress without treatment, showed deep dermal In contrast, treated with FIHC exhibited significantly reduced sunburn. Moreover, histopathological biochemical assays confirmed by topical application FIHC, which had potentially elasticity maintained imbalanced enzyme non-enzymatic antioxidant activity. Our findings amply demonstrate accelerated recovery lesions through down-regulation photodamage.